Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity
The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its associated or related disorders and conditions. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by cachexia, and its associated or related disorders and conditions and/or cachexia, and its associated or related disorders and conditions, such as for example, cancer cachexia and cachexia associated with AIDS, autoimmune disorders, drug addiction, alcoholism, chronic inflammatory disorders, cirrhosis of the liver, anorexia and neurodegenerative disease.; In particular, the diagnostic marker and drug target of the invention is the ATGL Lipase, which can be inhibited by e.g. siRNAs and compounds with any of the following structures (I).
A method for identifying a compound that prevents, ameliorates and/or inhibits cachexia and/or its associated or related disorders and conditions, comprising: (a) contacting a compound with a cell expressing ATGL polypeptide; and (b) measuring the expression and/or activity of ATGL in the presence or absence of said compound, wherein a compound that blocks or reduces the expression and/or activity of ATGL is identified as a compound that inhibits cachexia.